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Richard L. Deem - work

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Richard Deem earned his bachelor of science degree in biological sciences at the University of Southern California. He received his master of science degree in microbiology from California State University, Los Angeles, and has been working in basic science research since 1976. He has authored and co-authored a number of studies, included several areas of molecular biology and genetics, immunology, inflammatory bowel disease (1-17), natural killer cells (18-22), and infectious diseases (23-24). In addition, he has presented his work at a number of national and international scientific meetings.

Mr. Deem has been working for Dr. Stephan Targan since 1983 and is employed as a Senior Researcher/Specialist in the Inflammatory Bowel Disease Center at Cedars-Sinai Medical Center. He is currently collaborating with Dr. Rivkah Gonsky on the role of T-cells in inflammatory bowel disease, specifically on transactivating nuclear factors involved in activation pathways of lamina propria (gut-associated) T-cells.


Publications by Richard Deem available on Medline

  1. Gonsky R, Deem RL, Targan, SR. Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells.
    Cytokine, Available online 30 April 2013. DOI 10.1016/j.cyto.2013.04.004.
  2. Gonsky R, Deem RL, Landers CJ, Derkowski CA, Berel D, McGovern, DPB, Targan, SR. Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens.
    Inflammatory Bowel Diseases 2010. DOI 10.1002/ibd.21352
  3. Gonsky R, Deem RL, Targan SR. Distinct Methylation of IFNG in the Gut.
    J Interferon Cytokine Res. 2009 May 18.
    PMID: 19450149 [PubMed - as supplied by publisher]
  4. Gonsky R, Deem RL, Bream JH, Young HA, Targan SR. An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells.
    Genes Immun. 2006 Jul;7(5):342-51. Epub 2006 May 25.
    PMID: 16724074 [PubMed - indexed for MEDLINE]
  5. Gonsky R, Deem RL, Bream J, Young HA, Targan SR. Enhancer Role of STAT5 in CD2 Activation of IFN-g Gene Expression.
    J. Immunol. 2004 Nov 15;173(10):6241-7.
    PMID: 15528362 [PubMed - indexed for MEDLINE]
  6. Gonsky R, Deem RL, Young HA, Targan SR.
    CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells.
    Eur J Immunol. 2003 May;33(5):1152-62.
    PMID: 12731040 [PubMed - indexed for MEDLINE]
  7. Papadakis KA, Prehn J, Moreno ST, Cheng L, Kouroumalis EA, Deem R, Breaverman T, Ponath PD, Andrew DP, Green PH, Hodge MR, Binder SW, Targan SR.
    CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.
    Gastroenterology. 2001 Aug;121(2):246-54.
    PMID: 11487533 [PubMed - indexed for MEDLINE]
  8. Gonsky R, Deem RL, Bream JH, Lee DH, Young HA, Targan SR.
    Mucosa-specific targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression.
    J Immunol. 2000 Feb 1;164(3):1399-407.
    PMID: 10640755 [PubMed - indexed for MEDLINE]
  9. Gonsky R, Deem RL, Lee DH, Chen A, Targan SR.
    CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.
    J Immunol. 1999 Jun 1;162(11):6621-9.
    PMID: 10352279 [PubMed - indexed for MEDLINE]
  10. Gonsky R, Deem RL, Hughes CC, Targan SR.
    Activation of the CD2 pathway in lamina propria T cells up-regulates functionally active AP-1 binding to the IL-2 promoter, resulting in messenger RNA transcription and IL-2 secretion.
    J Immunol. 1998 May 15;160(10):4914-22.
    PMID: 9590239 [PubMed - indexed for MEDLINE]
  11. Plevy SE, Landers CJ, Prehn J, Carramanzana NM, Deem RL, Shealy D, Targan SR.
    A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.
    J Immunol. 1997 Dec 15;159(12):6276-82.
    PMID: 9550432 [PubMed - indexed for MEDLINE]
  12. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB.
    The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.
    J Clin Invest. 1995 May;95(5):2111-9.
    PMID: 7738178 [PubMed - indexed for MEDLINE]
  13. Targan SR, Deem RL, Liu M, Wang S, Nel A.
    Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.
    J Immunol. 1995 Jan 15;154(2):664-75.
    PMID: 7529282 [PubMed - indexed for MEDLINE]
  14. Andus T, Targan SR, Deem R, Toyoda H.
    Measurement of tumor necrosis factor alpha mRNA in small numbers of cells by quantitative polymerase chain reaction.
    Reg Immunol. 1993 Jan-Feb;5(1):11-7.
    PMID: 8347466 [PubMed - indexed for MEDLINE]
  15. Targan SR, Deem RL, Shanahan F.
    Role of mucosal T-cell-generated cytokines in epithelial cell injury.
    Immunol Res. 1991;10(3-4):472-8. Review. No abstract available.
    PMID: 1955774 [PubMed - indexed for MEDLINE]
  16. Deem RL, Shanahan F, Targan SR.
    Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells.
    Clin Exp Immunol. 1991 Jan;83(1):79-84.
    PMID: 1899066 [PubMed - indexed for MEDLINE]
  17. Deem RL, Targan SR, Niederlehner A, Shanahan F.
    The CD8+ Leu-7+ subset of T cells in Crohn's disease: distinction between cytotoxic and covert suppressor functions.
    Clin Exp Immunol. 1990 Jun;80(3):387-94.
    PMID: 1695560 [PubMed - indexed for MEDLINE]
  18. Shanahan F, Leman B, Deem R, Niederlehner A, Brogan M, Targan S.
    Enhanced peripheral blood T-cell cytotoxicity in inflammatory bowel disease.
    J Clin Immunol. 1989 Jan;9(1):55-64.
    PMID: 2522935 [PubMed - indexed for MEDLINE]
  19. Deem RL, Shanahan F, Niederlehner A, Targan SR.
    Role of the CD45 (T-200) molecule in anti-CD3-triggered T cell-mediated cytotoxicity.
    Cell Immunol. 1988 Nov;117(1):99-110.
    PMID: 2972397 [PubMed - indexed for MEDLINE]
  20. Shanahan F, Deem R, Nayersina R, Leman B, Targan S.
    Human mucosal T-cell cytotoxicity.
    Gastroenterology. 1988 Apr;94(4):960-7.
    PMID: 2450050 [PubMed - indexed for MEDLINE]
  21. Deem RL, Britvan LJ, Targan SR.
    Definition of a secondary target cell trigger during natural killer cell cytotoxicity: possible role of phospholipase A2.
    Cell Immunol. 1987 Dec;110(2):253-64.
    PMID: 3690677 [PubMed - indexed for MEDLINE]
  22. Deem RL, Niederlehner A, Targan SR.
    Active target cell processes, possibly involving receptor-mediated endocytosis, are critical for expression of cytotoxicity by natural killer cell-derived cytolytic factor.
    Cell Immunol. 1986 Oct 1;102(1):187-97.
    PMID: 3802200 [PubMed - indexed for MEDLINE]
  23. Deem RL, Targan SR.
    Analysis of sequential substages of the natural killer cell lethal hit.
    Adv Exp Med Biol. 1985;184:239-56. No abstract available.
    PMID: 3929573 [PubMed - indexed for MEDLINE]
  24. Deem RL, Targan SR.
    Sequential substages of natural killer cell-derived cytolytic factor (NKCF)-mediated cytolysis as defined by glutaraldehyde modulation of the target cell.
    J Immunol. 1984 Oct;133(4):1836-40.
    PMID: 6432901 [PubMed - indexed for MEDLINE]
  25. Deem RL, Targan SR.
    Evidence of a dynamic role of the target cell membrane during the early stages of the natural killer cell lethal hit.
    J Immunol. 1984 Jul;133(1):72-7.
    PMID: 6427347 [PubMed - indexed for MEDLINE]
  26. Deem RL, Doughty FA, Beaman BL.
    Immunologically specific direct T lymphocyte-mediated killing of Nocardia asteroides.
    J Immunol. 1983 May;130(5):2401-6.
    PMID: 6339627 [PubMed - indexed for MEDLINE]
  27. Deem RL, Beaman BL, Gershwin ME.
    Adoptive transfer of immunity to Nocardia asteroides in nude mice.
    Infect Immun. 1982 Dec;38(3):914-20.
    PMID: 6759412 [PubMed - indexed for MEDLINE]

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Last Modified May 6, 2013

 

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